The Daily Mail warns there is "no hope of normality" until July, following comments from the head of Oxford University's Covid-19 vaccines team. Prof Andrew Pollard said facemasks and social distancing would be needed until next summer, even if his global trial proves successful.
The i says Sir Keir has broken the "Covid consensus" in his calls for a national lockdown, although he said schools should remain open. Meanwhile, the paper says the "united front" between No 10 and scientists is also fraying as some Tory MPs push back against tougher rules.
The Guardian also sees Sir Keir as "heaping pressure" on the prime minister. It describes his comments as "a significant escalation of his criticism", with the Labour leader accusing Mr Johnson of having "lost control of the virus".
The Times has seen the same paper, and says it predicts a two-week full lockdown from 24 October, with stay at home orders and school closures, could reduce deaths for the rest of the year from about 19,900 to 12,100. However, the Times says Mr Johnson "hardened his stance" during a call with Tory MPs, saying it would not be right to impose the restrictions on areas where cases were still low.
"Lockdown battle begins", is the headline for the Telegraph, which says the prime minister will consider a "circuit breaker" lockdown if his new tier system fails to reverse the spread of the virus. The paper says a decision will be taken toward the end of next week, ahead of the half-term holiday, but regional circuit breakers are also under consideration.
Meanwhile, amid the rise in Covid-19 cases, the Metro reports the prime minister made a joke about his rule of six restrictions, suggesting people might welcome it "as an excuse to avoid their in-laws this Christmas". Mr Johnson is said to have made the remark as he faced Tory MPs at a Zoom meeting of the party's 1922 Committee of backbenchers on Tuesday night.
The Financial Times says Mr Johnson is under "mounting pressure" to impose a short national lockdown, after the Labour leader's calls. His comments came ahead of the publication of a paper, seen by the FT, by two of the government's leading scientific advisers, which says thousands of coronavirus deaths could be avoided if a two-week lockdown were imposed.